About

Hi, my name is Jean! I am a scientist with 10 years of research experience in cellular and gene therapy, biomaterials, tissue engineering, and regenerative medicine. Great communication and time management skills with high productivity. Independent individual with a passion for product development and project management in the industry. Love bears and golden retrievers!

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Experience

Research Experience

Postdoctoral Associate, University of Pittsburgh (May 2018 - Dec 2020)

  • Established a porcine model to study optic nerve head mechanobiology
  • Manipulated gene expression using adeno-associated viruses in ocular cells
  • Investigated the effects of surface modification on endothelial cell growth
  • Co-authored an article of optic nerve head decellularization
  • Co-authored a book chapter of glaucoma and eye diseases
  • Co-authored an article of tissue-engineered vascular grafts

Graduate Student Researcher, University of Pittsburgh (Jul 2014 - Apr 2018)

  • Investigated the effects of platelet-rich plasma on stem cell chondrogenesis
  • Modeled impact-induced injury and osteoarthritic degeneration of articular cartilage
  • Co-authored a book chapter of musculoskeletal injury and repair
  • Co-authored an article of platelet-rich plasma for cartilage repair
  • Awarded International Foundation for Ethical Research (IFER) Graduate Fellowship

Laboratory Technician, University of Pittsburgh (Sep 2013 - Apr 2014)

  • Modeled subtype-specific size-controlled microtumors in vitro
  • Investigated effect of size and subtype on epithelial-mesenchymal transition-related gene expression

Graduate Student Researcher, Cornell University (Aug 2012 - May 2013)

  • Studied roles of interstitial flows in breast cancer cell migration on a microfluidic device
  • Designed experiments and analyzed results by ImageJ, MATLAB, Prism, and JMP
  • Presented two posters at 5th Annual BEE Research Symposium and BioExpo 2013
  • Co-authored an article in Lab on a Chip

Undergraduate Student Researcher, National Taiwan University (Sep 2010 - Jun 2012)

  • Applied a zinc ion probe to image neuronal cells and examined effects of enhancer nitric oxide
  • Reduced silica nanoparticle size by 75% for enhancement of drug delivery
  • Co-authored a book chapter of immunosensors
  • Awarded Mao-Sheng Chang Scholarship

Volunteer Experience

Human Resources Officer, EternalOne Bioindustry Club (Jan 2021 - present)

  • Recruited and onboarded new core team members
  • Maintained team records

Officer, Engineering Graduate Student Organization (May 2017 - Apr 2018)

  • Maintained organization accounts and distributed information to 1000+ engineering graduate students
  • Coordinated with 5+ transcribers and editors

Consultant, Fourth River Solutions (Jan 2017 - Dec 2017)

  • Completed 4 projects for local start-up companies in eleven months
  • Researched on new start-ups and explored potential engagements
  • Conducted 20 interviews with prosthetists and physicians for a prosthetics company
  • Completed market and revenue analysis for a food recovery organization
  • Analyzed licensing models and licensees for a software start-up
  • Planned and recruited 12 different teams for Pittsburgh Health Innovation Case Competition

Transcriber, TED Conferences (Jan 2017 - Dec 2017)

  • Transcribed TEDx Talks and enabled the ideas to cross languages and borders
  • Transcribed TEDx Talks and enabled the ideas to cross languages and borders

Certifications

  • Project Management Foundations, Project Management Institute, 2021
  • Project Management Foundations: Risk, Project Management Institute, 2021
  • Project Management: Healthcare Projects, Project Management Institute, 2021
  • Comparing EMA and Health Canada CTA submission for Phase I trials to US FDA IND application, European Pharmaceutical Review, 2021

Education

  • PhD in Bioengineering, University of Pittsburgh, 2018
  • MEng in Biomedical Engineering, Cornell University, 2013
  • BS in Biochemical Science and Technology, National Taiwan University, 2012

Publications

  1. Liou, J. J., Drewry, M. D., Sweeney, A., Brown, B. N., & Vande Geest, J. P. (2020) Decellularizing the porcine optic nerve head: towards a model to study the mechanobiology of glaucoma, Translational Vision Science & Technology, 9(8), 17.
  2. Liou, J. J., Shoemaker, J. E., & Vande Geest, J. P. (2020) Mechanobiology of the Optic Nerve Head in Primary Open Angle Glaucoma, Mechanobiology, Chapter 1.3.
  3. Ardila, D. C., Liou, J. J., Maestas, D., Slepian, M. J., Badowski, M., Wagner, W. R., Harris, D., & Vande Geest, J. P. (2019) Surface Modification of Electrospun Scaffolds for Endothelialization of Tissue-Engineered Vascular Grafts Using Human Cord Blood-Derived Endothelial Cells, Journal of Clinical Medicine, 8(2), 185.
  4. Liou, J. J., Rothrauff, B. B., Alexander, P. G., & Tuan, R. S. (2018) Effect of Platelet-Rich Plasma on Chondrogenic Differentiation of Adipose- and Bone Marrow-Derived Mesenchymal Stem Cells, Tissue Engineering Part A, 24(19-20):1432-1443.
  5. Liou, J. J., Langhans, M. T., Gottardi, R., & Tuan, R. S. (2015) Injury and Repair of Tendon, Ligament, and Meniscus, Advances in Translational Medicine Regenerative Medicine, Chapter 6.
  6. Tung, C. K., Krupa, O., Apaydin, E., Liou, J. J., Diaz-Santana, A., Kim, B. J., & Wu, M. (2013) A contact line pinning based microfluidic platform for modelling physiological flows, Lab on a chip, 13(19):3876-3885.
  7. Ho, J. A., Lai, Y. H., Wu, L. C., Liang, S. H., Wong, S. L., & Liou, J. J. (2012) Analysis of Biotin (Vitamin B7) and Folic Acid (Vitamin B9): A Focus on Immunosensor Development with Liposomal Amplification, B Vitamins and Folate, Chapter 23.

Presentations

Podium

  1. Liou, J. J. (2020) Mechanobiology of the Optic Nerve Head in Primary Open Angle Glaucoma. Podium presentation at Bridgeside Seminar, University of Pittsburgh, Pittsburgh, PA.
  2. Liou, J. J. (2017) Engineering Graduate Student Organization Industry Career Preparation. Podium presentation at University of Pittsburgh, Pittsburgh, PA.
  3. Liou, J. J. & Tuan, R. S. (2017) Application of Platelet-Rich Plasma in Combination with Cell-Based Therapy for Cartilage Repair. Podium presentation at Bridgeside Seminar, University of Pittsburgh, Pittsburgh, PA.
  4. Liou, J. J. & Tuan, R. S. (2017) Application of Platelet-Rich Plasma in Combination with Cell-Based Therapy for Cartilage Repair. Podium presentation at Bioengineering Day, University of Pittsburgh, Pittsburgh, PA.
  5. Liou, J. J. & Tuan, R. S. (2016) Regenerative Repair of Traumatic Articular Cartilage Injuries: Point-of-Care Applications of Mesenchymal Stem Cells and Chondrocytes. Podium presentation at Bridgeside Seminar, University of Pittsburgh, Pittsburgh, PA.

Poster

  1. Liou, J. J. & Vande Geest, J.P. (2020) Effect of transforming growth factor beta 2 on matrix metalloproteinase activity in porcine lamina cribrosa cells. Poster presented at Association for Research in Vision and Ophthalmology (ARVO), Baltimore, MD.
  2. Vande Geest, J.P., Liou, J. J., Sweeney, A., Drewry, M. D., & Brown, B. N. (2020) A decelluarization and recellularization platform to study optic nerve head remodeling. Poster presented at Association for Research in Vision and Ophthalmology (ARVO), Baltimore, MD.
  3. Liou, J. J., Tien, S., Yee, M., Kinchington, P. R., Girkin, C. A., & Vande Geest, J.P. (2019) Manipulating Gene Expression of Human Lamina Cribrosa Cells and Astrocytes. Poster presented at Carnegie Mellon Forum on Biomedical Engineering, Pittsburgh, PA.
  4. Liou, J. J., Tien, S., Yee, M., Kinchington, P. R., Girkin, C. A., & Vande Geest, J.P. (2019) Manipulating Gene Expression of Human Lamina Cribrosa Cells and Astrocytes. Poster presented at Association for Research in Vision and Ophthalmology (ARVO), Vancouver, Canada.
  5. Drewry, M. D., Liou, J. J., Krahe, D., Brown, B. N., & Vande Geest, J. P. (2019) Decellularized optic nerve head model to study glaucoma biomechanics. Poster presented at Association for Research in Vision and Ophthalmology (ARVO), Vancouver, Canada.
  6. Liou, J. J., Ardila, D. C., Behrangzade, A., Furdella, K. J., & Vande Geest, J. P. (2019) Cord Blood-Derived Endothelialization of Tissue Engineered Vascular Grafts. Poster presented at the McGowan Retreat, Pittsburgh, PA.
  7. Liou, J. J., Tamimi, E., Behkam, R., Kollech, H., Hill, A., Ardila, C., & Vande Geest, J.P. (2019) Extracellular Matrix Organization and Biomechanics of the Lamina Cribrosa in Populations at High Risk for Glaucoma. Poster presented at the McGowan Retreat, Pittsburgh, PA.
  8. Liou, J. J., Tamimi, E., Behkam, R., Kollech, H., Hill, A., Ardila, C., & Vande Geest, J.P. (2018) Extracellular Matrix Organization and Biomechanics of the Lamina Cribrosa in Populations at High Risk for Glaucoma. Poster presented at Carnegie Mellon Forum on Biomedical Engineering, Pittsburgh, PA.
  9. Liou, J. J. & Tuan, R. S. (2018) Application of Platelet-Rich Plasma in Combination with Cell-Based Therapy for Cartilage Repair. Poster presented at the Orthopaedic Research Society (ORS) Annual Meeting, New Orleans, LA.
  10. Liou, J. J. & Tuan, R. S. (2018) Application of Platelet-Rich Plasma in Combination with Cell-Based Therapy for Cartilage Repair. Poster presented at the American Academy of Orthopedic Surgeons (AAOS) Biologics Symposium, Stanford, CA.
  11. Liou, J. J., Rothrauff, B. B., Alexander, P. G., & Tuan, R. S. (2017) Vascular Endothelial Growth Factor May Impair Prochondrogenic Activity of Platelet Rich Plasma on Human Adipose Stem Cells. Poster presented at Sixth Annual Symposium on Regenerative Rehabilitation, Pittsburgh, PA.
  12. Liou, J. J., Rothrauff, B. B., Alexander, P. G., & Tuan, R. S. (2017) Vascular Endothelial Growth Factor May Impair Prochondrogenic Activity of Platelet Rich Plasma on Human Adipose Stem Cells. Poster presented at Science 2017, Pittsburgh, PA.
  13. Liou, J. J. & Tuan, R. S. (2017) Vascular endothelial growth factor may impair pro-chondrogenic activity of platelet rich plasma on human adipose stem cells. Poster presented at the International Society for Stem Cell Research (ISSCR), Boston, MA.
  14. Liou, J. J., Rothrauff, B. B., Alexander, P. G., & Tuan, R. S. (2017) Vascular Endothelial Growth Factor May Impair Prochondrogenic Activity of Platelet Rich Plasma on Human Adipose Stem Cells. Poster presented at Bioengineering Day, Pittsburgh, PA.
  15. Liou, J. J., Rothrauff, B. B., Alexander, P. G., & Tuan, R. S. (2016) Platelet-Rich Plasma Impairs Chondrogenesis of Infrapatellar Fat Pad Derived Adipose Stem Cells In Vitro. Poster presented at 15th Annual McGowan Retreat, Farmington, PA.
  16. Liou, J. J., Rothrauff, B. B., Alexander, P. G., & Tuan, R. S. (2015) Effects of Platelet Rich Plasma on Bone Marrow Derived Mesenchymal Stem Cells and Adipose Stem Cells for Cartilage Repair. Poster presented at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) World Congress, Boston, MA.
  17. Liou, J. J., Rothrauff, B. B., Alexander, P. G., & Tuan, R. S. (2015) Effects of platelet rich plasma on bone marrow derived mesenchymal stem cells and adipose stem cells for cartilage repair. Poster presented at Bioengineering Day 2015, Pittsburgh, PA.
  18. Liou, J. J., Rothrauff, B. B., Alexander, P. G., & Tuan, R. S. (2015) Effects of platelet rich plasma on bone marrow derived mesenchymal stem cells and adipose stem cells for cartilage repair. Poster presented at 14th Annual McGowan Retreat, Farmington, PA.
  19. Liou, J. J., Mukundan, S., Jaramillo, M., Sant, V., Oesterriech, S., & Sant, S. (2014) Tumor size and subtype affects epithelial-mesenchymal transformation. Poster presented at the 13th Annual McGowan Retreat, Farmington, PA.
  20. Liou, J. J., Krupa, O., Tung, C. K., and Wu, M. (2013) A contact line pinning based microfluidic platform for modeling intramural and interstitial flows. Poster presented at the 5th Annual BEE Research Symposium, Cornell University, Ithaca, NY.
  21. Tung, C. K., Krupa, O., Apaydin, E., Liou, J. J., Diaz-Santana, A., Stroock, A. D., and Wu, M. (2013) A contact line pinning based microfluidic device for modeling intramural and interstitial flows. Poster presented at the American Physical Society (APS) March Meeting, Baltimore, MD.
  22. Liou, J. J., Krupa, O., Tung, C. K., and Wu, M. (2013) Roles of interstitial flows in cancer cell migration revealed by a 3D microfluidic model. Poster presented at MEng Spring Poster Session, Cornell University, Ithaca, NY.

Projects

Completed

  1. Manipulating Gene Expression of Human Lamina Cribrosa Cells and Astrocytes
  2. Development of an Ex Vivo Model to Study Optic Nerve Head Remodeling
  3. Effects of Transforming Growth Factor Beta 2 on Retinal Ganglion Cell Health
  4. Cord Blood-Derived Endothelialization of Tissue Engineered Vascular Grafts
  5. Application of Platelet-Rich Plasma in Combination with Cell-Based Therapy for Cartilage Repair
  6. Effects of Mechanical Impacts and Inflammatory Cytokines on Cartilage Explants and Chondrocyte Hydrogels
  7. Application of Human iPSC-derived Mesenchymal Progenitor Cells to Develop Osteochondral Microtissues for Osteoarthritis Drug Testing
  8. Effects of Size and Subtype of Microtumors on Epithelial-Mesenchymal Transition
  9. Roles of Physical Factors That Guide Sperm Migration in the Cervix and Uterotubal Junction
  10. Roles of Interstitial Flows in Breast Cancer Cell Migration on a Microfluidic Device
  11. Development of a Zinc Ion Probe to Image Neuronal Cells
  12. Fabrication of Silica Nanoparticles for Drug Delivery
  13. Analysis of Ingredient, Formula, and Amount in Chinese Medicine

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